In the horror-comedy blend “You’re Killing Me,” the film explores the perilous outcomes of modern dating amidst constant communication. Joe confesses to his boyfriend, George, that he is a serial killer. George, however, finds Joe’s revelation amusing and is more excited about spotting Patricia Arquette at Target. As Joe embraces his identity as a killer, George is preoccupied with choosing the perfect wig for his next YouTube appearance. But when George’s friends start vanishing mysteriously, he is forced to confront the harsh reality that Gretchen might not return with the crushed ice he requested for his party, despite the hashtag #YouDontNeedIceForChardonnay.