One year after the light of a supermoon awakened a latent gene, turning humans into ravenous werewolves and resulting in nearly a billion fatalities, the horror returns with the rise of the supermoon once more. Despite the efforts of two scientists to halt the mutation, they are unsuccessful, and those caught in the moonlight transform back into wild werewolves. As chaos takes over the streets, the scientists desperately try to reach a family member’s home, which is now besieged by the vicious beasts.