This reality show is based in the agricultural heartland of Central Michigan, showcasing the operations at Pol Veterinary Services. Dr. Pol, an expert in handling large farm animals, provides care for a variety of creatures including horses, pigs, cows, sheep, alpacas, goats, chickens, and sometimes even reindeer. The series also highlights the contributions of Dr. Brenda Grettenberger, who has been collaborating with Dr. Pol since 1992.