In the middle of the night, a body intended for organ donation inexplicably turns to ashes. Shortly thereafter, five individuals who received a heart, corneas, lungs, liver, and kidneys start to exhibit extraordinary abilities. A teenage girl becomes incredibly strong, a trendy individual can control electromagnetic fields, a writer can conjure powerful winds, a factory supervisor gains the power to heal others, and a woman uncovers a mysterious, yet-to-be-identified skill. Together, they form an unwilling yet valiant group called “HI-FIVE.” However, they are not the only ones changed. A cult leader who received the donor’s pancreas acquires the frightening ability to absorb life energy and aims to seize HI-FIVE’s powers to attain godlike supremacy.