In 1889, Italian immigrant Francesca Cabrini lands in New York City, only to find herself surrounded by illness, crime, and destitute children. Undeterred, she embarks on a bold quest to persuade the unwelcoming mayor to provide shelter and medical care for the city’s most at-risk individuals. Despite her limited English and frail health, Cabrini employs her innovative spirit to create an unprecedented beacon of hope for the world.