Dr. Henry Morgan, a leading medical examiner in New York City, harbors a hidden truth. He examines the deceased not only to crack criminal cases but also to uncover the enigma of his own mysterious immortality, a puzzle that has baffled him for two centuries. His extensive lifespan has endowed him with extraordinary observational abilities, which greatly impress his new colleague, Detective Jo Martinez. As they tackle new cases each week, their growing friendship gradually unveils the many facets of Henry’s extensive and vibrant history. The only person privy to Henry’s secret is his closest friend and confidant, Abe.