This comedy revolves around a large, joyful family navigating their sometimes awkward, often amusing, and ultimately heartwarming milestone moments, as recounted by different family members. Among the three siblings, the middle child, Matt, might have discovered true love with his colleague, Colleen. Meanwhile, the youngest brother, Greg, and his wife, Jen, are feeling overwhelmed by the arrival of their first baby. The eldest sibling, Heather, and her husband, Tim, are so anxious about their soon-to-be empty nest that they’re contemplating having another child. The parents, Joan, the devoted matriarch who supports her children as long as she agrees with their choices, and John, the sociable patriarch, are trying to ease the transition into his 70s. As the family’s stories unfold in four short segments each week, they strive to cherish these fleeting yet unforgettable moments, which collectively define the essence of life.